130-01-8 | 千里光宁
英文名称
SENECIONINE
分子式
C18H25NO5
分子量
335.39
结构式
中文别名
英文别名
| 属性 | 值 |
|---|---|
| BRN | 8162955 |
| LogP | 0.880 (est) |
| 密度 | 1.266 g/cm3 |
| 形态 | neat |
| 沸点 | 472.03°C (rough estimate) |
| 熔点 | 236 °C(lit.) |
| 颜色 | White to off-white |
| InChIKey | HKODIGSRFALUTA-JTLQZVBZSA-N |
| 折射率 | 1.5100 (estimate) |
| 溶解度 | DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.1 mg/ml |
| 储存条件 | −20°C |
| 外观性状 | 白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于菊三七，千里光Senecio scandens Buch.-Ham. ex D. Don，欧洲千里光 Senecio vulgaris L.全草 菊叶千里光 S.chrysanthemoides DC.根 牙克贝千里光 S.jacobaea L.。 |
| 比旋光度 | D25 -55.1° (c = 0.034 in chloroform) |
| 酸度系数(pKa) | 12.81±0.40(Predicted) |
| EPA化学物质信息 | Senecionine (130-01-8) |
| 旋光度 (Optical Rotation) | [α]25/D 55.1°, c = 0.034% in chloroform |
| 属性 | 值 |
|---|---|
| F | 10-23 |
| 毒性 | LD50 i.v. in mice: 64.12 ±2.24 mg/kg (Harris) |
| RTECS号 | VT5710000 |
| 警示词 | 危险 |
| WGK Germany | 3 |
| 包装类别 | II |
| 危险等级 | 6.1(a) |
| 安全说明 | 45 |
| 防范说明 | P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310 |
| 危险品标志 | T |
| 危险性描述 | H300+H310+H330 |
| 危险类别码 | 25 |
| 毒害物质数据 | 130-01-8(Hazardous Substances Data) |
| 危险性符号(GHS) | GHS06 |
| 危险品运输编号 | UN 2811 6.1/PG 3 |
| 标题 | 内容 |
|---|---|
| 用途1 | 用于含量测定/鉴定/药理实验等。 |
| 用途2 | 千里光宁具有凝血止血、消炎和抗病毒的作用。 |
| 标题 | 内容 |
|---|---|
| 体内研究 | Upon intravenous administration and oral administration of Senecionine and Adonifoline, significant differences in pharmacokinetics were observed, with the Senecionine and Adonifoline being absorbed fast with lower bioavailability and being quickly metabolized to PA N-oxides and hydroxylation products of PAs or their N-oxides. Senecionine fails to stimulate epoxide hydrase, it diminishs the activity of glutathione-s-transferase, aminopyrine demethylase and AHH. Twice-weekly injections of a third constituent, senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth. |
| 体外研究 | Pyrrolizidine alkaloids (PAs) are considered to be one of the most hepatotoxic groups of compounds of plant origin and are present in about 3% of the world's flowering plants. Most PAs represent a considerable health hazard to both livestock and humans through the consumption of plants and PA-contaminated products such as milk, honey, herbal teas, and medicines. |
| 生物活性 | Senecionine (Senecionan-11,16-dione, 12-hydroxy-) 是一种从 Senecio vulgaris 中分离出来的吡咯里西啶生物碱。 Senecionine对动物和人类有毒。 |
130-01-8
相关产品
| 商城编码 | 产品名称 | 标准值 | 规格 | CAS号 | 库存 | 标准价 | 品牌 | 数量 | 操作 |
|---|---|---|---|---|---|---|---|---|---|
| DQ0105-0020 | 千里光碱 |
HPLC≥98%
|
20mg/支
|
130-01-8
|
0
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2400.0
|
乐美天
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|
|
| ZPG-89789 | Senecionine|ZPG-89789|10mg|CAS:130-01-8 |
见证书
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10mg
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130-01-8
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0
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6650.0
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萘析精选
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|
| ZTR-S258650 | Senecionine|ZTR-S258650|0.25mg|CAS:130-01-8 |
见证书
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0.25mg
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130-01-8
|
0
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咨询
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萘析精选
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|
|
| CCPE901658 | 千里光宁|CCPE901658|≥95%|50mg|CAS:130-01-8 |
≥95%
|
50mg
|
130-01-8
|
0
|
9000.0
|
CATO
|
|
|
| CCPE901658 | 千里光宁|CCPE901658|98.8%|2.5mg|CAS:130-01-8 |
98.8%
|
2.5mg
|
130-01-8
|
0
|
咨询
|
CATO
|
|
|
| CCPE901658 | 千里光宁|CCPE901658|98.8%|0.25mg|CAS:130-01-8 |
98.8%
|
0.25mg
|
130-01-8
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0
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咨询
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CATO
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|
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| S-110001 | Senecionine|S-110001|100mg|CAS:130-01-8 |
见证书
|
100mg
|
130-01-8
|
0
|
咨询
|
萘析精选
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|
| RMCS068000-1mg | 标准物质/千里光宁/SENECIONINE相关化合物|RMCS068000-1mg|CAS:130-01-8 |
见证书
|
1mg
|
130-01-8
|
0
|
433.0
|
曼哈格
|
|
|
| CCPE901658 | 千里光宁|CCPE901658|98.8%|5mg|CAS:130-01-8 |
98.8%
|
5mg
|
130-01-8
|
0
|
2083.0
|
CATO
|
|
|
| CCPE901658 | 千里光宁|CCPE901658|>95%|25mg|CAS:130-01-8 |
>95%
|
25mg
|
130-01-8
|
0
|
5760.0
|
CATO
|
|
| 商城编码 | 产品名称 | 标准值 | 规格 | CAS号 | 库存 | 标准价 | 品牌 | 数量 | 操作 |
|---|---|---|---|---|---|---|---|---|---|
| R113802-1mg | Senecionine|R113802-1mg|98%|CAS:130-01-8 |
98%
|
1mg
|
130-01-8
|
0
|
1373.0
|
罗恩
|
|
|
| B29029-5mg | 千里光宁|B29029-5mg|HPLC≥97%|CAS:130-01-8 |
HPLC≥97%
|
5mg
|
130-01-8
|
6
|
1400.0
|
源叶
|
|
|
| 25145-1 mg | Senecionine|25145-1 mg|CAS:130-01-8 |
见详情
|
1 mg
|
130-01-8
|
0
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723.6
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萘析精选
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| 25145-10 mg | Senecionine|25145-10 mg|CAS:130-01-8 |
见详情
|
10 mg
|
130-01-8
|
0
|
3510.8
|
萘析精选
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|
|
| 25145-5 mg | Senecionine|25145-5 mg|CAS:130-01-8 |
见详情
|
5 mg
|
130-01-8
|
0
|
2479.0
|
萘析精选
|
|
| 商城编码 | 产品名称 | 标准值 | 规格 | CAS号 | 库存 | 标准价 | 品牌 | 数量 | 操作 |
|---|---|---|---|---|---|---|---|---|---|
| DRE-A16934000MW-100 | 千里光碱|Senecionine|130-01-8|100 μg/mL in Methanol:Water|Dr.E|1ml|标准物质（RM）-溶液型|DRE-A16934000MW-100 |
标准物质（RM）-溶液型
|
1ml
|
130-01-8
|
0
|
1856.0
|
Dr.E
|
|
|
| RMT24591-5mg | 千里光宁碱|RMT24591-5mg|99.0%|CAS:130-01-8 |
99.0%
|
5mg
|
130-01-8
|
6
|
2313.0
|
曼哈格
|
|
|
| RMT24591 | 千里光宁|RMT24591|97.8%|10mg|CAS:130-01-8 |
97.8%
|
10mg
|
130-01-8
|
2
|
3240.0
|
曼哈格
|
|
|
| 1ST40300-1000M | 甲醇中千里光宁碱溶液，1000μg/mL|1ST40300-1000M|1mL|CAS:130-01-8 |
1000μg/mL
|
1mL
|
130-01-8
|
0
|
840.0
|
First Standard
|
|
|
| 1ST40300-100M | 甲醇中千里光宁碱溶液，100μg/mL|1ST40300-100M|1mL|CAS:130-01-8 |
100μg/mL
|
1mL
|
130-01-8
|
0
|
504.0
|
First Standard
|
|
| 商城编码 | 产品名称 | 标准值 | 规格 | CAS号 | 库存 | 标准价 | 品牌 | 数量 | 操作 |
|---|---|---|---|---|---|---|---|---|---|
| ZDR-A16934000MW-100 | Senecionine 100 µg/mL in Methanol:Water|ZDR-A16934000MW-100|100 µg/mL于甲醇：水|1ml|CAS:130-01-8 |
100 µg/mL于甲醇：水
|
1ml
|
130-01-8
|
0
|
咨询
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萘析精选
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| ZHC-690574 | Senecionine|ZHC-690574|1ml(100 µg/ml)in Acetonitrile|CAS:130-01-8 |
见证书
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1ml(100 µg/ml)in Acetonitrile
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130-01-8
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0
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2670.0
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| ZCH-3818.18-100-ME | Senecionine|ZCH-3818.18-100-ME|100 µg/mL in methanol|1 mL|CAS:130-01-8 |
100 µg/mL in methanol
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1 mL
|
130-01-8
|
0
|
咨询
|
萘析精选
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|