153437-55-9 | 153437-55-9
英文名称
4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
分子式
C16H16ClN3O3
分子量
333.77
结构式
中文别名
英文别名
| 属性 | 值 |
|---|---|
| 形态 | 粉末 |
| 溶解度 | 溶于二甲基亚砜 |
| 储存条件 | -20°C储存 |
| 标题 | 内容 |
|---|---|
| 靶点 | EGFR 4 μM (IC 50 ) KDR 66 nM (IC 50 ) RET 5 nM (IC 50 ) |
| 体内研究 | WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis. |
| 生物活性 | WHI-P180 (Janex 3)是多种激酶抑制剂；抑制 RET，KDR 和 EGFR 的IC50 值分别为5 nM，66 nM 和4 μM。 |