480-54-6 | 倒千里光碱
英文名称
RETRORSINE
分子式
C18H25NO6
分子量
351.39
结构式
中文别名
英文别名
| 属性 | 值 |
|---|---|
| InChI | InChI=1S/C18H25NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,11,14-15,20,23H,5-10H2,1-2H3/b12-3-/t11-,14-,15-,18-/m1/s1 |
| Merck | 13,8253 |
| SMILES | N12CC=C3COC(=O)[C@@](O)(CO)[C@H](C)C/C(=C/C)/C(=O)O[C@@]([H])([C@]13[H])CC2 |
| 密度 | 1.32±0.1 g/cm3 (20 ºC 760 Torr) |
| 形态 | neat |
| 沸点 | 485.2°C (rough estimate) |
| 熔点 | 208-211 °C(lit.) |
| 颜色 | White to off-white |
| InChIKey | BCJMNZRQJAVDLD-VMOBWIEOSA-N |
| 折射率 | 1.5100 (estimate) |
| 储存条件 | ?20°C |
| 比旋光度 | D18 -17.6° (c = 1.99 in ethanol) |
| CAS 数据库 | 480-54-6 |
| 酸度系数(pKa) | 12.00±0.40(Predicted) |
| (IARC)致癌物分类 | 3 (Vol. 10, Sup 7) 1987 |
| EPA化学物质信息 | Retrorsine (480-54-6) |
| 属性 | 值 |
|---|---|
| RTECS号 | VH7525000 |
| 警示词 | 危险 |
| WGK Germany | 3 |
| 包装类别 | II |
| 危险等级 | 6.1(a) |
| 安全说明 | 22-36/37/39-45 |
| 防范说明 | P260-P262-P264-P280-P302+P352+P310-P304+P340+P310 |
| 危险品标志 | T |
| 危险性描述 | H300+H310+H330 |
| 危险类别码 | 25 |
| 毒害物质数据 | 480-54-6(Hazardous Substances Data) |
| 危险性符号(GHS) | GHS06 |
| 危险品运输编号 | 1544 |
| 标题 | 内容 |
|---|---|
| 体内研究 | Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle. Animal Model: Male Wistar rats (180±20 g), portal branch ligation (PBL) model Dosage: 30 mg/kg Administration: Intraperitoneal injection, twice, separated by 2-week interval Result: Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL. |
| 体外研究 | Retrorsine (60-240 μM; 24 hours) significantly reduces HSEC-CYP3A4 cells viability and GSH levels, and increases formation of pyrrole-protein adducts. Cell Viability Assay Cell Line: HSEC-CYP3A4 cells Concentration: 60 μM, 120 μM , 240 μM Incubation Time: 24 hours Result: Significantly decreased cell viability. |
| 生物活性 | Retrorsine 是一种天然存在的有毒吡咯利西啶生物碱。Retrorsine 可以与 DNA 结合，抑制肝细胞的增殖能力。Retrorsine 可用于肝细胞损伤的研究。 |
480-54-6
相关产品
| 商城编码 | 产品名称 | 标准值 | 规格 | CAS号 | 库存 | 标准价 | 品牌 | 数量 | 操作 |
|---|---|---|---|---|---|---|---|---|---|
| DD0392-0010 | 倒千里光碱 |
HPLC≥95%
|
10mg/支
|
480-54-6
|
0
|
2000.0
|
乐美天
|
|
|
| R-135001 | Retrorsine|R-135001|100mg|CAS:480-54-6 |
见证书
|
100mg
|
480-54-6
|
0
|
咨询
|
萘析精选
|
|
|
| CCPE901533 | 倒千里光碱|CCPE901533|≥95%|0.5mg|CAS:480-54-6 |
≥95%
|
0.5mg
|
480-54-6
|
0
|
咨询
|
CATO
|
|
|
| ZPG-89775 | Retrorsine|ZPG-89775|10mg|CAS:480-54-6 |
见证书
|
10mg
|
480-54-6
|
0
|
4820.0
|
萘析精选
|
|
|
| CCPE901533 | 倒千里光碱|CCPE901533|>95%|10mg|CAS:480-54-6 |
>95%
|
10mg
|
480-54-6
|
0
|
咨询
|
CATO
|
|
|
| CCPE901533 | 倒千里光碱|CCPE901533|>95%|5mg|CAS:480-54-6 |
>95%
|
5mg
|
480-54-6
|
0
|
咨询
|
CATO
|
|
|
| CCPE901533 | 倒千里光碱|CCPE901533|>95%|25mg|CAS:480-54-6 |
>95%
|
25mg
|
480-54-6
|
0
|
6000.0
|
CATO
|
|
|
| CCPE901533 | 倒千里光碱|CCPE901533|≥95%|10g|CAS:480-54-6 |
≥95%
|
10g
|
480-54-6
|
0
|
咨询
|
CATO
|
|
|
| ZT-30176 | 倒千里光碱|ZT-30176|95% (HPLC)|10 mg|CAS:480-54-6 |
95% (HPLC)
|
10 mg
|
480-54-6
|
0
|
1500.0
|
萘析精选
|
|
|
| ZCX-00018140-005 | 倒千里光碱(AS)|ZCX-00018140-005|5mg|CAS:480-54-6 |
见证书
|
5mg
|
480-54-6
|
0
|
咨询
|
萘析精选
|
|
| 商城编码 | 产品名称 | 标准值 | 规格 | CAS号 | 库存 | 标准价 | 品牌 | 数量 | 操作 |
|---|---|---|---|---|---|---|---|---|---|
| RMCR057000-1mg | 标准物质/倒千里光碱/RETRORSINE相关化合物 |
见证书
|
1mg
|
480-54-6
|
0
|
628.0
|
曼哈格
|
|
|
| DRE-A16812500WA-100 | 倒千里光碱|Retrorsine|480-54-6|100 μg/mL in Water|Dr.E|1ml|标准物质（RM）-溶液型|DRE-A16812500WA-100 |
标准物质（RM）-溶液型
|
1ml
|
480-54-6
|
0
|
1352.0
|
Dr.E
|
|
|
| RMT13555 | 倒千里光碱|RMT13555|10mg|CAS:480-54-6 |
见证书
|
10mg
|
480-54-6
|
0
|
2416.0
|
曼哈格
|
|
|
| 1ST40320-1000M | 甲醇中倒千里光碱溶液，1000μg/mL|1ST40320-1000M|1mL|CAS:480-54-6 |
1000μg/mL
|
1mL
|
480-54-6
|
0
|
1200.0
|
First Standard
|
|
|
| 1ST40320-100A | 乙腈中倒千里光碱溶液，100μg/mL|1ST40320-100A|1mL|CAS:480-54-6 |
100μg/mL
|
1mL
|
480-54-6
|
0
|
720.0
|
First Standard
|
|
|
| 1ST40320-100M | 甲醇中倒千里光碱溶液，100μg/mL|1ST40320-100M|1mL|CAS:480-54-6 |
100μg/mL
|
1mL
|
480-54-6
|
0
|
720.0
|
First Standard
|
|
| 商城编码 | 产品名称 | 标准值 | 规格 | CAS号 | 库存 | 标准价 | 品牌 | 数量 | 操作 |
|---|---|---|---|---|---|---|---|---|---|
| S26200-1mg | 倒千里光碱|S26200-1mg|90%|CAS:480-54-6 |
90%
|
1mg
|
480-54-6
|
3
|
550.0
|
源叶
|
|
|
| S26200-10mg | 倒千里光碱|S26200-10mg|90%|CAS:480-54-6 |
90%
|
10mg
|
480-54-6
|
0
|
1500.0
|
源叶
|
|
|
| V54025-1ml | 倒千里光碱|V54025-1ml|10mM in DMSO|CAS:480-54-6 |
10mM in DMSO
|
1ml
|
480-54-6
|
0
|
1650.0
|
源叶
|
|
|
| B27918-5mg | 倒千里光碱|B27918-5mg|HPLC≥95%|CAS:480-54-6 |
HPLC≥95%
|
5mg
|
480-54-6
|
7
|
2400.0
|
源叶
|
|
| 商城编码 | 产品名称 | 标准值 | 规格 | CAS号 | 库存 | 标准价 | 品牌 | 数量 | 操作 |
|---|---|---|---|---|---|---|---|---|---|
| ZDR-A16812500WA-100 | 倒千里光碱|ZDR-A16812500WA-100|100 µg/mL in 水|1ml|CAS:480-54-6 |
100 µg/mL in 水
|
1ml
|
480-54-6
|
0
|
咨询
|
萘析精选
|
|
|
| ZCH-3817.18-100-ME | Retrorcine|ZCH-3817.18-100-ME|100 µg/mL in methanol|1 mL|CAS:480-54-6 |
100 µg/mL in methanol
|
1 mL
|
480-54-6
|
0
|
咨询
|
萘析精选
|
|