58523-30-1 | PSEUROTIN A
英文名称
pseurotin
分子式
C22H25NO8
分子量
431.44
结构式
英文别名
| 属性 | 值 |
|---|---|
| 密度 | 1.41±0.1 g/cm3(Predicted) |
| 形态 | 白色至类白色粉末。 |
| 沸点 | 751.5±60.0 °C(Predicted) |
| 熔点 | 126.0-126.9℃ |
| 颜色 | 白色 |
| 溶解度 | 溶于DMSO(10mg/ml) |
| 稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
| 储存条件 | -20°C |
| 酸度系数(pKa) | 14.76±0.20(Predicted) |
| 标题 | 内容 |
|---|---|
| 体内研究 | Pseurotin A (10 mg/kg; p.o.; 7X/week, 30 days) shows anti-tumor activity. Animal Model: HFD-fed orthotopic athymic mice (bearing BT-474 tumor cells xenograft mode) Dosage: 10 mg/kg Administration: P.o.; 7X/week, 30 days Result: Significantly suppressed the growth of BT474 tumors. |
| 体外研究 | Pseurotin A inhibits the expression of PCSK9 in HepG2 cells, with an IC 50 value of 1.2 μM. Pseurotin A (25-100 μM; 72 hours) significantly suppressed the PCSK9 level in a dose dependent manner in BT-474 and T47D BC cell lines. Pseurotin A (25-100 μM; 72 hours) significantly increases LDLR level in a dose dependent manner. Pseurotin A (40-200 μM; 24-72 hours) shows anti-proliferative activity in the hormone-dependent BC cells. Cell Viability Assay Cell Line: BT-474 cells, T47D cells Concentration: 40-200 μM Incubation Time: 24-72 hours Result: Showed weak but time and dose-dependent inhibition of the growth of BT-474 and T47D BC cells, with gradual decrease of the IC 50 values over time (260.83-93.64 μM and 267.84-113.08 μM, respectively). |
| 生物活性 | Pseurotin A，曲霉和其他真菌的次级代谢产物，是几丁质合成酶 (chitin synthase) 的竞争性抑制剂和神经发生剂。Pseurotin A 抑制 IgE 的产生 (IC50=3.6 μM)。Pseurotin A 具有抗肿瘤活性。 |