68027-15-6 | Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
英文名称
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
分子式
C47H76O17
分子量
913.10
结构式
中文别名
英文别名
| 属性 | 值 |
|---|---|
| 密度 | 1.40±0.1 g/cm3 (20 ºC 760 Torr) |
| 形态 | 固体 |
| 沸点 | 997.6±65.0 °C(Predicted) |
| 熔点 | 239-241℃ |
| 颜色 | 白色至浅米色 |
| 溶解度 | 少许溶于甲醇、可溶于吡啶 |
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| 外观性状 | 白色粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于白头翁。 |
| 酸度系数(pKa) | 4.63±0.70(Predicted) |
| 标题 | 内容 |
|---|---|
| 用途1 | 药理药效:抗菌，抗肿瘤，镇静，镇痛 |
| 用途2 | 白头翁皂苷D具有抗菌，抗肿瘤，镇静，镇痛的作用。 |
| 标题 | 内容 |
|---|---|
| 靶点 | Target Value c-Met () |
| 体内研究 | Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model. Animal Model: 2x2x2 mm 3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice. Dosage: 6.4 mg/kg. Administration: Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day. Result: Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). |
| 体外研究 | Pulsatilla saponin D (SB365) shows apoptotic effect accompanied by increased evidence of cleaved caspase-3 and poly (ADP ribose) polymerase. Pulsatilla saponin D (SB365) strongly inhibits c-Met expression in gastric cancer cells. Pulsatilla saponin D (SB365) strongly suppresses the growth and proliferation of 5 human pancreatic cancer cell lines (MIAPaCa-2, BXPC-3, PANC-1, AsPC-1 and HPAC) . Pulsatilla saponin D (SB365) shows anti-angiogenic activity by decreasing the expression of HIF-1α and VEGF. Pulsatilla saponin D (0.3 ng/mL to 10 μg/mL) exhibits anti-tumor activity in NSCLC cancer cells. Cell Cytotoxicity Assay Cell Line: A-549, SKMEL-2, MCF-7, and Lewis lung carcinoma (LLC) cells. Concentration: 0.3 ng/mL to 10 μg/mL. Incubation Time: 72 h. Result: Exhibited an ED 50 value of 6.3 μg/mL for A-549 cells. |
| 生物活性 | Pulsatilla saponin D (SB365) 可从 Pulsatilla koreana Nakai 根部分离得到，具有抗癌活性。 |