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Mouse anti-Human IgM antibody [SA-DA4] (FITC)|GTX04300-06|500μg
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Mouse anti-Human IgM antibody [SA-DA4] (FITC)|GTX04300-06|500μg

GTX04300-06
Mouse anti-Human IgM antibody [SA-DA4] (FITC)
¥ 5300.0
¥ 5300.0
500μg
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Mouse anti-Human IgM antibody [SA-DA4] (FITC)介绍：

产品名称:
Mouse anti-Human IgM antibody [SA-DA4] (FITC)
反应种属:
Human
宿主来源:
Mouse
实验应用:
ELISA, FCM, ICC/IF, IHC-Fr, IP, Multiplexing, WB
同种型:
IgG1
免疫原:
Human IgM myeloma protein
克隆性:
Monoclonal
克隆号:
SA-DA4
纯化方式:
Purified IgG1
偶联:
FITC
产品浓度:
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. Protect from light.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, 0.09 % sodium azide.
生产商:
GeneTex
功能与背景:
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010]

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