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Nicastrin antibody|GTX23444|100μg
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Nicastrin antibody|GTX23444|100μg

GTX23444
Nicastrin antibody
¥ 5300.0
¥ 5300.0
100μg
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Nicastrin antibody介绍：

产品名称:
Nicastrin antibody
别名:
nicastrin , ATAG1874
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB
同种型:
IgG
免疫原:
Synthetic Peptide: C(688) I N A K A D V L F I A P R E P G A V S Y(708)
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
78
产品形式:
Liquid
存储溶液:
PBS, 0.1% BSA, 0.05% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]

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