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RWDD3 antibody|GTX85245|100μg
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RWDD3 antibody|GTX85245|100μg

GTX85245
RWDD3 antibody|GTX85245|100μg
¥ 6200.0
¥ 6200.0
100μg
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RWDD3 antibody介绍：

产品名称:
RWDD3 antibody
别名:
RWD domain containing 3 , RSUME
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
ELISA, WB
靶标/特异性:
This antibody is specific for RWDD3 N-Terminus
同种型:
IgG
免疫原:
RWDD3 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human RWDD3.The immunogen is located within the first 50 amino acids of RWDD3.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
31
产品形式:
Liquid
存储溶液:
PBS, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune–inflammatory signals. RWDD3 increases Ikbeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikbeta increased stability. RSUME-enhanced sumoylation of Ikbeta leads to the inhibition of NF-kbeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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