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ERR gamma antibody, Internal|GTX88809|100μg
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ERR gamma antibody, Internal|GTX88809|100μg

GTX88809
ERR gamma antibody, Internal
¥ 5600.0
¥ 5600.0
100μg
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ERR gamma antibody, Internal介绍：

产品名称:
ERR gamma antibody, Internal
别名:
estrogen related receptor gamma , ERR-gamma , ERR3 , ERRg , ERRgamma , NR3B3
反应种属:
Human
宿主来源:
Goat
实验应用:
WB
靶标/特异性:
This antibody is expected to recognise the reported isoform NP_001429.2.
同种型:
IgG
免疫原:
Peptide with sequence CRMSNKDRHIDS, from the internal region of the protein sequence according to NP_001429.2; NP_996317.1; NP_996318.1.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by ammonium sulphate precipitation followed by antigen affinity chromatography
偶联:
Unconjugated
产品浓度:
0.50 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
51
产品形式:
Liquid
存储溶液:
TBS, 0.5% BSA, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]

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