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MDMX / MDM4 (phospho Ser367) antibody|GTX55445|100μl
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MDMX / MDM4 (phospho Ser367) antibody|GTX55445|100μl

GTX55445
MDMX / MDM4 (phospho Ser367) antibody
¥ 5300.0
¥ 5300.0
100μl
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MDMX / MDM4 (phospho Ser367) antibody介绍：

产品名称:
MDMX / MDM4 (phospho Ser367) antibody
别名:
MDM4 regulator of p53 , HDMX , MDMX , MRP1
反应种属:
Human
宿主来源:
Rabbit
实验应用:
IHC-P, WB
同种型:
IgG
免疫原:
Peptide sequence around phosphorylation site of serine 367 (T-I-S(p)-A-P) derived from human MDMX.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by antigen-affinity chromatography. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
55
产品形式:
Liquid
存储溶液:
PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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