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BRCA1 antibody [MS110]|GTX16780|50μg
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BRCA1 antibody [MS110]|GTX16780|50μg

GTX16780
BRCA1 antibody [MS110]
¥ 5300.0
¥ 5300.0
50μg
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BRCA1 antibody [MS110]介绍：

产品名称:
BRCA1 antibody [MS110]
别名:
BRCA1 DNA repair associated , BRCAI , BRCC1 , BROVCA1 , FANCS , IRIS , PNCA4 , PPP1R53 , PSCP , RNF53
反应种属:
Human
宿主来源:
Mouse
实验应用:
ICC/IF, IHC-Fr, IHC-P, IP, WB
靶标/特异性:
GTX16780 doesnot cross-react with blood group antigens or growth factor receptors such as EGFR.
同种型:
IgG1
免疫原:
Recombinant full length protein (Human).
克隆性:
Monoclonal
克隆号:
MS110
偶联:
Unconjugated
产品浓度:
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
预期分子量:
208
产品形式:
Liquid
存储溶液:
50mM Sodium Phosphate, 0.2% Gelatin, 0.1% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009]

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