跳至内容
当前位置: 首页 产品中心 分析试剂 生物试剂 Her2 / ErbB2 antibody [HL5814]|GTX647132|100μl
Her2 / ErbB2 antibody [HL5814]介绍:

产品名称:
Her2 / ErbB2 antibody [HL5814]
别名:
erb-b2 receptor tyrosine kinase 2 , CD340 , HER-2 , HER-2/neu , HER2 , MLN 19 , NEU , NGL , TKR1
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
靶标/特异性:
This antibody is specific for human ErbB2 protein and does not cross react with human EGFR protein.
同种型:
IgG
免疫原:
Recombinant fragment encompassing a sequence within the Intracellular domain of human Her2 / ErbB2. The exact sequence is proprietary.
克隆性:
Monoclonal
克隆号:
HL5814
纯化方式:
Affinity purified by Protein A.
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

本公司销售的所有产品仅供实验科研使用,不用于人体及临床诊断。

暂无标准解读内容
暂无常见问题内容