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E7449|21658-10 mg|CAS:1140964-99-3

产品编号

21658-10 mg

英文名称

E7449

标准价

~~¥ 4060.2~~

优惠价

¥ 4060.2

CAS号

1140964-99-3

规格

10 mg

有效期

品牌

萘析精选

标准值

见详情

数量

− +

库存

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E7449介绍：

产品名称:

E7449

产品描述:

An inhibitor of PARP1, PARP2, and TNKS1/2 (IC50s = 1, 1.2, and 50-11 nM, respectively); selective for PARP1, PARP2, and TNKS1/2 over PARP3 and PARP6-15 (IC50s = >3 μM); inhibits growth of DT40 cells in a PARP-dependent manner (IC50s = 3.2 and >15 μM for wild-type and PARP-/- cells, respectively); decreases expression of Wnt/β-catenin signaling pathway proteins in SW480 cells; enhances antitumor activity of temozolomide and carboplatin in a B16/F10 isograft model and MX-1 mouse xenograft model, respectively; inhibits tumor growth in a BRCA1 mutant MDA-MB-436 breast cancer mouse xenograft model at 30 and 100 mg/kg per day; delays hair regrowth in mice following hair removal

保存温度:

-20

运输温度:

-20

预期分子量:

317.3

产品形式:

A crystalline solid

有效期:

1460

纯度:

≥98%

CAS号:

1140964-99-3

分子式:

C18H15N5O

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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