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PLX5622|28927-10 mg|CAS:1303420-67-8
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PLX5622|28927-10 mg|CAS:1303420-67-8

28927-10 mg
PLX5622
¥ 2036.8
¥ 2036.8
1303420-67-8
10 mg
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PLX5622介绍：

产品名称:
PLX5622
产品描述:
A brain-penetrant CSF1R inhibitor (IC50 = 0.016 µM); selective for CSF1R over FLT3, Kit, Aurora C, and VEGFR2 (IC50s = 0.39, 0.86, 1, and 1.1 µM, respectively); greater than 100-fold selective for CSF1R over a panel of 230 kinases; reduces the number of Iba-1+ cells in the spinal cord dorsal horn in a mouse model of neuropathic pain induced by partial ligation of the sciatic nerve at 65 mg/kg; decreases macrophage levels of TNF-α and IL-1β and infiltration in the sciatic nerve and alleviates mechanical and cold allodynia in the same model; decreases the number of hippocampal microglia by 90%, as well as reduces the number and volume of retrosplenial and somatosensory cortical Aβ plaques in the 5XFAD mouse model of Alzheimer's disease at 1,200 ppm
保存温度:
-20
运输温度:
-20
预期分子量:
395.405466
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
1303420-67-8
分子式:
C21H19F2N5O

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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