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AV-412|29039-25 mg|CAS:451493-31-5

产品编号

29039-25 mg

英文名称

AV-412

标准价

~~¥ 6244.4~~

优惠价

¥ 6244.4

CAS号

451493-31-5

规格

25 mg

有效期

品牌

萘析精选

标准值

见详情

数量

− +

库存

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AV-412介绍：

产品名称:

AV-412

别名:

MP-412

产品描述:

A dual inhibitor of EGFR and HER2 (IC50s = 1.4, 0.51, 0.79, 2.3, and 19 nM for the EGFR, EGFRL858R, EGFRT790M, EGFRL858R,T790M, and HER2 recombinant intracellular kinase domains, respectively); selective for EGFR and HER2 over IRK, MEK1, PKA, and PKC (IC50s = >10 μM) but also inhibits Abl, FLT1, and Src (IC50s = 41, 920, and 2,000 nM, respectively); induces ubiquitination and degradation of HER2 in SK-BR-3 cells at 10 and 30 μM; decreases levels of HER2 and ERα and increases levels of Hsp70 in MCF-7 cells at 10 μM; inhibits EGF-stimulated growth of A431 cells (IC50 = 0.1 μM); reduces tumor growth in an A431 mouse xenograft model at 10 and 30 mg/kg and in a BT-474 mouse xenograft model at 30 mg/kg

保存温度:

-20

运输温度:

-20

预期分子量:

507.002163

产品形式:

A solid

有效期:

1460

纯度:

≥98%

CAS号:

451493-31-5

分子式:

C27H28ClFN6O • 2C7H8O3S

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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