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AS-252424|10009052-10 mg|CAS:900515-16-4
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AS-252424|10009052-10 mg|CAS:900515-16-4

10009052-10 mg
AS-252424
¥ 2787.2
¥ 2787.2
900515-16-4
10 mg
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AS-252424介绍：

产品名称:
AS-252424
产品描述:
A PI3Kγ and ACSL4 inhibitor; inhibits PI3Kγ (IC50 = 0.03 µM); selective for PI3Kγ over PI3Kα, PI3Kβ, and PI3Kδ (IC50s = 0.94, 20, and 20 µM, respectively) but also inhibits CK2 (IC50 = 0.02 µM); prevents decreases in viability induced by RSL3 in HT-1080 cells in an ACSL4-dependent manner; nanoparticles loaded with AS-252424 reduce inflammation and ferroptosis in an ACSL4-dependent manner in the kidney and liver in mouse models of renal pedicle clamping-induced ischemia-reperfusion injury and concanavalin A-induced acute liver injury, respectively; reduces c-Kit ligand-induced LTC4 production and cPLA2, JNK, and p38 MAPK phosphorylation in bone marrow-derived mast cells at 0.5-2.5 µM; increases airway hyperresponsiveness and airway smooth muscle thickening in a mouse model of toluene diisocyanate-induced asthma at 10 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
305.3
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥95%
CAS号:
900515-16-4
分子式:
C14H8FNO4S

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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