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Pemetrexed (sodium salt hydrate)|14269-5 mg|CAS:357166-29-1
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Pemetrexed (sodium salt hydrate)|14269-5 mg|CAS:357166-29-1

14269-5 mg
Pemetrexed (sodium salt hydrate)|14269-5 mg|CAS:357166-29-1
¥ 911.2
¥ 911.2
357166-29-1
5 mg
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Pemetrexed (sodium salt hydrate)介绍：

产品名称:
Pemetrexed (sodium salt hydrate)
产品描述:
An antifolate with anticancer activity; an inhibitor of thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively); has increased potency for thymidylate kinase when polyglutaminated (Ki = 1.3 nM); an inhibitor of glycinamide ribonucleotide formyltransferase (Kis = 9,300 and 65 nM for the non-glutaminated and polyglutaminated enzyme) and aminoimidazole carboxamide ribonucleotide formyltransferase (Kis = 3,600 and 265 nM for the non-glutaminated and polyglutaminated, respectively); inhibits proliferation of CCRF-CEM cells but not 5,10-dideazatetrahydrofolate-resistant CR15 cells (IC50s = 0.254 and 200 µM, respectively); reduces tumor growth in A549, H1299, and PC-9 NSCLC mouse xenograft models but not in models using the same cell lines overexpressing thymidylate kinase
保存温度:
-20
运输温度:
-20
预期分子量:
597.5
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
357166-29-1
分子式:
C20H19N5O6 • 2Na [7H2O]

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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