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E17241|41675-10 mg|CAS:1060968-92-4
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E17241|41675-10 mg|CAS:1060968-92-4

41675-10 mg
E17241
¥ 4649.8
¥ 4649.8
10 mg
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E17241介绍:

产品名称:
E17241
别名:
4-(1,3-Dithiolan-2-yl)-N-(3-hydroxypyridin-2-yl)benzamide
产品描述:
An inducer of ABCA1 expression; induces the expression of ABCA1 in a reporter assay using HepG2 cells (EC50 = 280 nM); an agonist of PPARs; induces PPAR-mediated gene expression in reporter assays using HepG2 cells expressing PPARγ, PPARα, or PPARδ (EC50s = 290, 3,900, and 879 nM, respectively); increases the protein levels of ACBA1 in RAW 264.7 cells but not in the presence of siRNA targeting mRNA encoding PKCζ; increases cholesterol efflux in RAW 264.7 cells at 0.4, 2, or 10 µM; reduces plasma levels of cholesterol, ALT, and AST and hepatic levels of cholesterol and triglycerides, as well as decreases aortic lesion area in an ApoE-/- mouse model of atherosclerosis when administered at a dose of 25 mg/kg; decreases plasma glucose levels and body weight in KKAy diabetic mice fed a HFHG diet at 50 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
318.41594
产品形式:
A solid
有效期:
1460
纯度:
≥95%
CAS号:
1060968-92-4
分子式:
C15H14N2O2S2

本公司销售的所有产品仅供实验科研使用,不用于人体及临床诊断。

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