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H3B-5942|31454-1 mg|CAS:2052128-15-9
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H3B-5942|31454-1 mg|CAS:2052128-15-9

31454-1 mg
H3B-5942
¥ 656.6
¥ 656.6
2052128-15-9
1 mg
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H3B-5942介绍：

产品名称:
H3B-5942
产品描述:
A selective estrogen receptor covalent antagonist; covalently modifies cysteine 530 in the ligand binding domain of wild-type ERα and ERαY537S; inhibits expression of the ERα target genes GREB1 and TFF1 in MCF-7 cells overexpressing wild-type ERα (IC50s = 2.74 and 1.3 nM, respectively), ERαY537S (IC50s = 29.38 and 19.4 nM, respectively), ERαY537N (IC50s = 8.14 and 6.1 nM, respectively), ERαY537C (IC50s = 12.19 and 9.5 nM, respectively), or ERαD538G (IC50s = 24.87 and 4 nM, respectively); inhibits the growth of MCF-7 cells overexpressing wild-type ERα or ERαY537S (GI50s = 1.3 and 8.3 nM, respectively); reduces tumor growth in an MCF-7 mouse xenograft model and an ERαY537S/WT ST941 PDX mouse model in a dose-dependent manner
保存温度:
-20
运输温度:
-20
预期分子量:
494.62742
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
2052128-15-9
分子式:
C31H34N4O2

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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