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ARN3236|31457-5 mg|CAS:1613710-01-2
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ARN3236|31457-5 mg|CAS:1613710-01-2

31457-5 mg
ARN3236
¥ 2854.2
¥ 2854.2
5 mg
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ARN3236介绍:

产品名称:
ARN3236
产品描述:
An inhibitor of SIK2 (IC50 = 50s = 21.63 and 6.63 nM, respectively); inhibits TNF-α secretion in RAW 264.7 cells (IC50 = ~2.5 µM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 µM; inhibits growth of 10 ovarian cancer cell lines (IC50s = 0.8-2.6 µM) and increases sensitivity of eight of them to paclitaxel; halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 µM; has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
336.40862
产品形式:
A crystalline solid
有效期:
1460
纯度:
≥98%
CAS号:
1613710-01-2
分子式:
C19H16N2O2S

本公司销售的所有产品仅供实验科研使用,不用于人体及临床诊断。

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