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Trametinib (DMSO solvate)|44750-50 mg|CAS:1187431-43-1
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Trametinib (DMSO solvate)|44750-50 mg|CAS:1187431-43-1

44750-50 mg
Trametinib (DMSO solvate)
¥ 1179.2
¥ 1179.2
1187431-43-1
50 mg
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Trametinib (DMSO solvate)介绍：

产品名称:
Trametinib (DMSO solvate)
别名:
GSK1120212|JTP-74057
产品描述:
An inhibitor of MEK1 and -2; inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3.4 and 1.8 nM, respectively) and MEK2 (IC50s = 1.6 and 0.92 nM, respectively); inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0.48 and 0.52 nM) and seven cell lines expressing mutant K-Ras (IC50s = 2.2-174 nM) but does not inhibit the growth of COLO 320DM cells expressing both wild-type B-RAF and wild-type K-Ras (IC50 = >10,000 nM); reduces tumor growth in HT-29 and COLO 205 mouse xenograft models at 0.3 and 1 mg/kg per day; decreases M. tuberculosis-induced increases in hind paw volume in a rat model of arthritis at 0.03 and 0.1 mg/kg per day
保存温度:
-20
运输温度:
-20
预期分子量:
615.403873
产品形式:
A solid
有效期:
1460
纯度:
≥98%
CAS号:
1187431-43-1
分子式:
C26H23FIN5O4 • C2H6OS

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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