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Eclitasertib|45472-10 mg|CAS:2125450-76-0
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Eclitasertib|45472-10 mg|CAS:2125450-76-0

45472-10 mg
Eclitasertib
¥ 2720.2
¥ 2720.2
2125450-76-0
10 mg
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Eclitasertib介绍：

产品名称:
Eclitasertib
别名:
DNL758|SAR443122
产品描述:
A RIPK1 inhibitor (IC50 = 0.0375); inhibits necroptosis induced by TNF-α, a Smac mimetic, and Z-VAD-FMK in HT-29 cells (EC50 = 0.0154 µM, respectively); inhibits necroptosis induced by IFN-γ, TNF-α, Z-VAD, and an Smac mimetic and reduces cytokine levels induced by the same combination in primary human keratinocytes at 4 nM; reduces epidermal thickness, reverses disruptions in epidermal architecture, and reduces IL-1RA release in 3D keratinocyte skin equivalents generated from primary human keratinocytes and stimulated with mixed lesional T cell supernatants prepared from LP and CLE patient-derived skin biopsies; reverses TNF-α- and Z-VAD-induced hypothermia in a mouse model of systemic inflammatory response syndrome
保存温度:
-20
运输温度:
-20
预期分子量:
378.392
产品形式:
A solid
有效期:
1460
纯度:
≥98%
CAS号:
2125450-76-0
分子式:
C19H18N6O3

本公司销售的所有产品仅供实验科研使用，不用于人体及临床诊断。

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