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Adavivint|43927-1 mg|CAS:1467093-03-3
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Adavivint|43927-1 mg|CAS:1467093-03-3

43927-1 mg
Adavivint
¥ 375.2
¥ 375.2
1 mg
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Adavivint介绍:

产品名称:
Adavivint
别名:
Lorecivivint|SM-04690
产品描述:
An inhibitor of Wnt signaling (EC50 = 19.5 nM in a reporter assay using SW480 cells); inhibits CMGC family kinases, including Clk2 and DYRK1A (IC50s = 7.8 and 26.9 nM, respectively), as well as Clk1, Clk3, Clk4, DYRK1B, GSK3β, and HIPK1-3 (IC50s = 16.8-239 nM); induces activation of YAP in a reporter assay using HEK293A cells (EC50 = 1.2 nM); induces chondrogenesis in primary human bone marrow-derived MSCs; inhibits pseudorabies virus replication in infected HeLa, BHK-21, Vero, and PK(15) cells (IC50s = 0.16, 0.19, 0.22, and 0.35 µM, respectively); intra-arterial administration decreases disease severity in a surgically induced rat model of osteoarthritis at 0.3 µg/animal; inhibits tumor growth in a patient-derived organoid xenograft mouse model of colorectal cancer at 50 mg/kg
保存温度:
-20
运输温度:
-20
预期分子量:
505.557403
产品形式:
A solid
有效期:
1460
纯度:
≥98%
CAS号:
1467093-03-3
分子式:
C29H24FN7O

本公司销售的所有产品仅供实验科研使用,不用于人体及临床诊断。

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